The ISG engages in a range of activities in prevention advocacy. It holds periodic conferences and lectures, often co-sponsored with universities and other partners, including human rights and refugee organizations, and has produced a number of publications and reports. The Institute also runs the biennial Raphael Lemkin Book Award, which recognizes prominent and ground-breaking works on the causes and prevention of genocide and mass atrocities. The ISG provides consultation to representatives of the media, governmental and non-governmental organizations, and advocates for passage of legislation and administrative measures related to genocide and other gross violations of human rights.
The ISG is a member of the Alliance Against Genocide, an international coalition of nongovernmental organizations dedicated to genocide and mass atrocity prevention. To advance research and cooperation, the ISG initiated the organization of the International Association of Genocide Scholars in 1995, an autonomous affiliate of the ISG.